rs10193576 chr2:219177905 A>C
- Sequence
cagtgcgttgagggttggttgagt[A/C]atgggacggccaccgcccttcccg
- ASB in cell types
- HepG2 (hepatoblastoma) MDA-MB-231-1833 (breast cancer cells, bone-tropic metastatic line) ESO-26 (Gastroesophageal junction adenocarcinoma) HEK293 (embryonic kidney)
- ASB for transcription factors
- JUN_HUMAN KLF5_HUMAN CDN1B_HUMAN GCR_HUMAN
View in PheLiGe Color scale
-log10 FDR of Ref (A) ASB
-log10 FDR of Alt (C) ASB
Details
Transcription factors
Cell types
Uniprot ID | Effect size Ref | Effect size Alt | FDR Ref | FDR Alt | Mean BAD | Motif fold change | Motif concordance | |
|---|---|---|---|---|---|---|---|---|
| JUN_HUMAN | -0.62 | 1.76 | 1.17 | 4.60 | Concordant | |||
| KLF5_HUMAN | n/a | 2.32 | 2.00 | n/a | No Hit | |||
| CDN1B_HUMAN | 0.09 | 2.11 | 1.00 | n/a | n/a | |||
| GCR_HUMAN | -0.03 | 1.15 | 1.00 | n/a | No Hit | |||
| CREB1_HUMAN | 0.42 | 1.55 | 1.57 | n/a | No Hit |
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Motif analysis
Genetic associations
GTEx eQTL Adipose_Subcutaneous, Adipose_Visceral_Omentum, Artery_Aorta, Artery_Coronary, Artery_Tibial, Brain_Cerebellar_Hemisphere, Brain_Cerebellum, Brain_Hippocampus, Brain_Hypothalamus, Brain_Putamen_basal_ganglia, Brain_Spinal_cord_cervical_c-1, Brain_Substantia_nigra, Breast_Mammary_Tissue, Cells_Cultured_fibroblasts, Cells_EBV-transformed_lymphocytes, Colon_Transverse, Esophagus_Gastroesophageal_Junction, Esophagus_Mucosa, Esophagus_Muscularis, Heart_Left_Ventricle, Lung, Muscle_Skeletal, Nerve_Tibial, Pancreas, Pituitary, Prostate, Skin_Not_Sun_Exposed_Suprapubic, Skin_Sun_Exposed_Lower_leg, Spleen, Stomach, Testis, Thyroid, Whole_Blood