rs11185315 - ADASTRA v6.1.1

rs11185315 chr1:108327903 A>G

Sequence: gtttcctcccaccagagggcagtt[A/G]tgacctgggagatctctcttggtg
ASB in cell types: MCF7 (Invasive ductal breast carcinoma) K562 (myelogenous leukemia) GM02610 (Lymphoblastoid Cell Lines) 2588 (Lymphoblastoid Cell Lines)
ASB for transcription factors: CTCF_HUMAN RAD21_HUMAN STAG1_HUMAN E4F1_HUMAN
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0.05
FDR threshold
0
ES threshold

Color scale

-log10 FDR of Ref (A) ASB

-log10 FDR of Alt (G) ASB

Details

Transcription factors

Cell types

Uniprot ID	Effect size Ref	Effect size Alt	FDR Ref	FDR Alt	Mean BAD	Motif fold change	Motif concordance
CTCF_HUMAN	0.05	2.53	1.00	6.2·10^-41	1.89	0.98	Weak Concordant
RAD21_HUMAN	0.69	2.58	1.00	1.6·10^-10	1.51	n/a	n/a
STAG1_HUMAN	0.14	2.38	1.00	1.2·10^-6	1.06	n/a	n/a
E4F1_HUMAN	n/a	2.59	1.00	0.02	1.00	n/a	No Hit

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Motif analysis

CTCF_HUMAN

Weak Concordant

Genetic associations

GRASP mitral annular calcium, total cholesterol

GTEx eQTL Artery_Tibial, Brain_Anterior_cingulate_cortex_BA24, Brain_Cerebellar_Hemisphere, Brain_Cerebellum, Esophagus_Mucosa, Esophagus_Muscularis, Pancreas, Pituitary, Skin_Sun_Exposed_Lower_leg, Testis