rs2735075 chr6:29976766 T>G

Sequence
cggcccggagttcactgcgaggac[T/G]gggatcacccatcaccccgccctg
ASB in cell types
K562 (myelogenous leukemia) HepG2 (hepatoblastoma) UCLA1 hESCs HCT-116 (colon carcinoma)
ASB for transcription factors
HDAC1_HUMAN ZFX_HUMAN AP2C_HUMAN NCOR1_HUMAN
Search SNPs nearby
View in UCSC Genome Browser
View in PheLiGe

Color scale

color scale ref
-log10 FDR of Ref (T) ASB
color scale alt
-log10 FDR of Alt (G) ASB

Details

Uniprot ID
Effect size Ref
Effect size Alt
FDR Ref
FDR Alt
Mean BAD
Motif fold change
Motif concordance
HDAC1_HUMAN n/a 2.38 1.002.2·10-3 3.00 n/a n/a
ZFX_HUMAN -0.66 1.88 1.002.5·10-3 1.50 -2.51 Discordant
AP2C_HUMAN 2.79 -2.86 4.4·10-31.00 1.00 n/a No Hit
NCOR1_HUMAN n/a 2.58 1.000.01 3.00 n/a n/a
MEIS2_HUMAN n/a 3.14 1.000.02 3.00 n/a No Hit
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Motif analysis

ZFX_HUMAN Discordant
ZFX_HUMAN pic

Genetic associations

GRASP advanced age-related macular degeneration,  advanced age-related macular degeneration (choroidal neovascularization) vs. no amd,  hdl cholesterol change with statins,  ldl cholesterol,  rheumatoid arthritis,  triglycerides
GTEx eQTL Adipose_Subcutaneous,  Adipose_Visceral_Omentum,  Adrenal_Gland,  Artery_Aorta,  Artery_Coronary,  Artery_Tibial,  Brain_Amygdala,  Brain_Anterior_cingulate_cortex_BA24,  Brain_Caudate_basal_ganglia,  Brain_Cerebellar_Hemisphere,  Brain_Cerebellum,  Brain_Cortex,  Brain_Frontal_Cortex_BA9,  Brain_Hippocampus,  Brain_Hypothalamus,  Brain_Nucleus_accumbens_basal_ganglia,  Brain_Putamen_basal_ganglia,  Brain_Spinal_cord_cervical_c-1,  Brain_Substantia_nigra,  Breast_Mammary_Tissue,  Cells_Cultured_fibroblasts,  Cells_EBV-transformed_lymphocytes,  Colon_Sigmoid,  Colon_Transverse,  Esophagus_Gastroesophageal_Junction,  Esophagus_Mucosa,  Esophagus_Muscularis,  Heart_Atrial_Appendage,  Heart_Left_Ventricle,  Kidney_Cortex,  Liver,  Lung,  Minor_Salivary_Gland,  Muscle_Skeletal,  Nerve_Tibial,  Ovary,  Pancreas,  Pituitary,  Prostate,  Skin_Not_Sun_Exposed_Suprapubic,  Skin_Sun_Exposed_Lower_leg,  Small_Intestine_Terminal_Ileum,  Spleen,  Stomach,  Testis,  Thyroid,  Uterus,  Vagina,  Whole_Blood

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