rs772556 - ADASTRA v6.1.0

rs772556 chr12:62910667 C>T

Sequence: accatgactgagagaattagctga[C/T]gaaggaagggcttagcagttgctt
ASB in cell types: K562 (myelogenous leukemia) CD34+ hematopoietic stem cells-derived proerythroblasts embryonic stem cells derived definitive endoderm
ASB for transcription factors: TAL1_HUMAN PBX2_HUMAN REQU_HUMAN SMRC2_HUMAN
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0.05
FDR threshold
0
ES threshold

Color scale

-log10 FDR of Ref (C) ASB

-log10 FDR of Alt (T) ASB

Details

Transcription factors

Cell types

Uniprot ID	Effect size Ref	Effect size Alt	FDR Ref	FDR Alt	Mean BAD	Motif fold change	Motif concordance
TAL1_HUMAN	0.33	1.96	1.00	5.1·10^-7	2.50	n/a	No Hit
PBX2_HUMAN	n/a	2.28	1.00	1.8·10^-5	2.00	n/a	No Hit
REQU_HUMAN	n/a	2.91	1.00	1.2·10^-4	4.00	n/a	n/a
SMRC2_HUMAN	n/a	3.77	1.00	3.3·10^-4	2.00	n/a	n/a
GATA1_HUMAN	2.55	2.54	4.7·10^-4	1.00	1.90	3.08	Discordant

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Motif analysis

GATA1_HUMAN

Discordant

ZNF24_HUMAN

Concordant

ATF3_HUMAN

Weak Discordant

Genetic associations

GRASP bipolar disorder, irritible bowel syndrome, microalbuminuria, parkinsons disease, partial epilepsy, sporadic creutzfeldt-jakob disease, urinary albumin-to-creatinine ratio

GTEx eQTL Muscle_Skeletal, Whole_Blood