rs174561 chr11:61815236 T>C
- Sequence
caatcgccgtccccgccgcggcat[T/C]cccggccccaaatcacactgcggg
- ASB in cell types
- T47D (invasive ductal carcinoma) MCF10A (breast epithelial cells) renal cortex HepG2 (hepatoblastoma)
- ASB for transcription factors
- TEAD4_HUMAN RBM25_HUMAN CREB1_HUMAN NRF1_HUMAN
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-log10 FDR of Ref (T) ASB
-log10 FDR of Alt (C) ASB
Details
Transcription factors
Cell types
Uniprot ID | Effect size Ref | Effect size Alt | FDR Ref | FDR Alt | Mean BAD | Motif fold change | Motif concordance | |
|---|---|---|---|---|---|---|---|---|
| TEAD4_HUMAN | 4.37 | -4.17 | 1.00 | -4.22 | Concordant | |||
| RBM25_HUMAN | 1.57 | -1.27 | 2.00 | n/a | n/a | |||
| CREB1_HUMAN | 1.34 | -0.31 | 1.58 | n/a | No Hit | |||
| NRF1_HUMAN | 1.69 | 0.13 | 1.25 | n/a | No Hit | |||
| SP1_HUMAN | 2.31 | -1.97 | 1.00 | 3.73 | Discordant |
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Motif analysis
Genetic associations
GTEx eQTL Adipose_Subcutaneous, Adipose_Visceral_Omentum, Artery_Aorta, Artery_Tibial, Brain_Anterior_cingulate_cortex_BA24, Brain_Caudate_basal_ganglia, Brain_Cerebellar_Hemisphere, Brain_Cerebellum, Brain_Cortex, Brain_Frontal_Cortex_BA9, Brain_Hippocampus, Brain_Hypothalamus, Brain_Putamen_basal_ganglia, Brain_Spinal_cord_cervical_c-1, Breast_Mammary_Tissue, Cells_Cultured_fibroblasts, Colon_Sigmoid, Colon_Transverse, Esophagus_Gastroesophageal_Junction, Esophagus_Mucosa, Esophagus_Muscularis, Heart_Atrial_Appendage, Heart_Left_Ventricle, Liver, Lung, Muscle_Skeletal, Nerve_Tibial, Ovary, Pancreas, Prostate, Skin_Sun_Exposed_Lower_leg, Small_Intestine_Terminal_Ileum, Spleen, Stomach, Testis, Thyroid, Whole_Blood