GRASP advanced age-related macular degeneration (geographic atrophy), decrease in fev1/fvc ratio (in asthmatic participants), lung function, ratio of forced expiratory volume in 1 second (fev1) to forced vital capacity (fvc) (fev1/fvc) ratio percent predicted (in asthmatic participants), obesity with early age of onset (age >2), rheumatoid arthritis, serum creatinine, total cholesterol change with statins